刘蕾


博士副研究员

通讯地址:北京工商大学理学院

邮编:100048

电子信箱:liulei@btbu.edu.c

 

个人简历

1998.09 - 2002.07 中国农业大学生物学院生物科学专业学士

2002.09 - 2007.07 中国农业大学生物学院生理学博士

2007.07 - 2011.12 中国科学院动物研究所助理研究员

2012.01 - 2015.07 中国科学院动物研究所副研究员

2015.08 至今北京工商大学理学院副研究员

 

研究领域

动物细胞模型在化妆品功效及安全性评价中的应用

 

学术成就

主要从事细胞生物学及发育生物学研究,利用细胞模型开展细胞干性、发育潜能研究及应用安全性评估,并对其调控自我更新和分化的分子机制进行探索。工作期间共发表SCI论文17篇,以第一或共同第一作者发表论文3篇(第一作者影响因子共计21.776),先后主持4项国家级项目,申请发明专利1项。

 

发表论文

1. Li Z, Wang L, Wang Y, Liu L, Wang L, Li W, Zhou Q. Generation of an LncRNA Gtl2-GFP Reporter for Rapid Assessment of Pluripotency in Mouse Induced Pluripotent Stem Cells. J Genet Genomics. 20;42(3) (2015):125-8. IF=2.924

2. Guo CL#, Liu L#, Jia YD, Zhao XY, Zhou Q, Wang L*. A novel variant of Oct3/4 gene in mouse embryonic stem cells. Stem Cell Research9(2) (2012):69-76.(共同第一作者)IF=4.467

3. Li W#, Shuai L#, Wan HF#, Dong MZ#, Wang M, Sang LS, Feng CJ, Luo GZ, Li TD, Li X, Wang LB, Zheng QY, Sheng C, Wu HJ, Liu ZH, Liu L, Wang L, Wang XJ, Zhao XY*, Zhou Q*. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 490(7420) (2012):407-411.  IF=42.351

4. Sheng C#, Zheng QY#, Wu JY#, Xu Z, Sang LS, Wang LB, Guo CL, Zhu WW, Tong M, LiuL, Li W, Liu ZH, Zhao XY, Wang L, Chen ZG*, Zhou Q*. Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors. Cell Research22(4)(2012):769-772.  IF=11.981

5. Sheng C#, Zheng QY#, Wu JY#, Xu Z, Wang LB, Li W, Zhang HJ, Zhao XY, Liu L, Wang ZW, Guo CL, Wu HJ, Liu ZH, Wang L, He SG, Wang XJ, Chen ZG*, Zhou Q*. Direct reprogramming of sertoli cells into multipotent neural stem cells by defined factors. Cell Research22(1) (2012):208-218. IF=11.981

6. Li TD#, Zhao XY#, Teng F, Li X, Jiang MG, Li W, Wang XP, Wang JL, Liu L, Liu ZH, Wang L, Zhou Q*. Derivation of Germline Competent Rat Embryonic Stem Cells from DA Rats. Journal of Genetics and Genomics39(11) (2012):603-606.  IF=2.924

7. Gu Q#, Hao J#, Zhao XY, Li W, Liu L, Wang L, Liu ZH, Zhou Q*. Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions. Protein & Cell 3(1) (2012):71-79.  IF=3.22

8. Tong M#, Lv Z#, Liu L#, Zhu H#, Zheng QY#, Zhao XY, Li W, Wu YB, Zhang HJ, Wu HJ, Li ZK, Zeng FY, Wang L, Wang XJ, Sha JH*, Zhou Q*. Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis. Cell Research21(11) (2011):1634-1637.(共同第一作者)IF=11.981

9. Li W#, Zhao XY#, Wan HF, Zhang Y, Liu L, Lv Z, Wang XJ, Wang L*, Zhou Q*. iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation. Cell Research21(3) (2011):550-553.  IF=11.981

10. Riaz A#, Zhao XY#, Dai XP#, Li W, Liu L, Wan HF, Yu Y, Wang L, Zhou Q*. Mouse cloning and somatic cell reprogramming using electrofusedblastomeres. Cell Research 21(5) (2011):770-778.  IF=11.981

11. Liu L#, Luo GZ#, Yang W#, Zhao XY#, Zheng QY, Lv Z, Li W, Wu HJ, Wang L, Wang XJ*, Zhou Q*. Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. Journal of Biological Chemistry 285(25) (2010):19483-19490.  IF=5.328

12. Zhou SY#, Ding CH#, Zhao XY#, Wang EY, Dai XP, Liu L, Li W, Liu ZC, Wan HF, Feng CJ, Hai H, Wang L, Zhou Q*. Successful generation of cloned mice using nuclear transfer from induced pluripotent stem cells. Cell Research20(7) (2010):850-853.  IF=11.981

13. Zhao XY#, Li W#, Lv Z#, Liu L, Tong M, Hai T, Hao J, Wang X, Wang L, Zeng FY*, Zhou Q*. Viable fertile mice generated from fully pluripotent iPS cells derived from adult somatic cells. Stem Cell Reviews and Reports 6(3) (2010):390-397. IF=6.774

14. Zhao XY#, Li W#, Lv Z#, Liu L, Tong M, Hai T, Hao J, Guo CL, Wang X, Wang L, Zeng FY*, Zhou Q*. Efficient and rapid generation of induced pluripotent stem cells using alternative culture medium. Cell Research20(3)(2010):383-386.  IF=11.981

15. Zhao XY, Lv Z, Liu L, Wang L, Tong M, Zhou Q*. Derivation of embryonic stem cells from Brown Norway rats blastocysts. Journal of Genetics and Genomics37(7) (2010):467-473.  IF=2.924

 

16. Zhao XY#, Li W#, Lv Z#, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng FY*, Zhou Q*. iPS cells produce viable mice through tetraploid complementation. Nature461(7260)(2009):86-90.  IF=42.351

撰写专著

1. 《再生医学——理论与技术》,科学出版社,2010年,北京

2.《新生物学年鉴2013》,科学出版社,2013年,北京

3.《生物学实验指南丛书——干细胞实验指南》,中央广播电视大学出版社,2015年,北京

 

 

 


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